Invitrogen™ COX10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556900

Catalog No. PIPA556900

Description

Immunogen sequence: CVGGSVWYLE RRTIQDSPHK FLHLLRNVNK QWITFQHFSF LKRMYVTQLN RSHNQQVRPK PEPVASPFLE KTSSGQAKAE IYEMRP Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 66%.

Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.

Specifications

• Antigen: COX10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COX10
• Gene Alias: 2410004F01Rik; AU042636; COX10; COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor; cytochrome c oxidase assembly homolog 10; cytochrome c oxidase assembly protein; cytochrome c oxidase assembly protein 10; cytochrome c oxidase subunit X; heme A: farnesyltransferase; heme O synthase; LOC691853; Protoheme IX farnesyltransferase, mitochondrial; similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1352
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q12887
• Gene Symbols: COX10
• Immunogen: Recombinant protein corresponding to Human COX10. Recombinant protein control fragment (Product #RP-95547).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov