Invitrogen™ COX15 Monoclonal Antibody (2D2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA518633

Catalog No. PIMA518633

Description

Peptide Sequence: LTESGLSMVD WHLIKEMKPP TSQEEWEAEF QRYQQFPEFK ILNHDMTLTE FKFIWYMEYS H.

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein belonging to the COX15/ctaA family. Existing as two alternatively spliced isoforms, COX15 is predominantly expressed in tissues containing high rates of oxidative phosphorylation including brain, heart and muscle. COX15 defects are the cause of a neurodegenerative disorder known as Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).

Specifications

• Antigen: COX15
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q7KZN9
• Gene Symbols: COX15
• Immunogen: COX15 (NP_510870, 92 a.a. ~ 152 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 2D2
• Conjugate: Unconjugated
• Gene: COX15
• Gene Alias: 2900026G05Rik; CEMCOX2; COX15; COX15 cytochrome c oxidase assembly homolog; COX15 homolog, cytochrome c oxidase assembly protein; COX15, cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly homolog 15; cytochrome c oxidase assembly homolog 15 (yeast); cytochrome c oxidase assembly protein 15; cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1355
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid