Invitrogen™ COX15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530253

Catalog No. PIPA530253

Description

Recommended positive controls: Jurkat. Predicted reactivity: Mouse (92%), Rat (91%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein belonging to the COX15/ctaA family. Existing as two alternatively spliced isoforms, COX15 is predominantly expressed in tissues containing high rates of oxidative phosphorylation including brain, heart and muscle. COX15 defects are the cause of a neurodegenerative disorder known as Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).

Specifications

• Antigen: COX15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COX15
• Gene Alias: 2900026G05Rik; CEMCOX2; COX15; COX15 cytochrome c oxidase assembly homolog; COX15 homolog, cytochrome c oxidase assembly protein; COX15, cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly homolog 15; cytochrome c oxidase assembly homolog 15 (yeast); cytochrome c oxidase assembly protein 15; cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1355
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q7KZN9
• Gene Symbols: COX15
• Immunogen: Recombinant protein encompassing a sequence within the center region of human COX15. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov