Invitrogen™ COX15 Polyclonal Antibody

Catalog No.	Quantity
PIPA589973	100 μL

Catalog No. PIPA589973 Supplier Invitrogen™ Supplier No. PA589973

Description

Rabbit Polyclonal Antibody

Immunogen sequence: YSHRMWGRLV GLVYILPAAY FWRKGWLSRG MKGRVLALCG LVCFQGLLGW YMVKSGLEEK SDSHDIPRVS QYRLAAHLGS ALVLYCASLW TSLSLLLPPH K; Positive Samples: U-251MG, A-431, Jurkat, Mouse heart, Mouse kidney, Mouse lung, Rat testis; Cellular Location: Mitochondrion membrane, Multi-pass membrane protein.

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein belonging to the COX15/ctaA family. Existing as two alternatively spliced isoforms, COX15 is predominantly expressed in tissues containing high rates of oxidative phosphorylation including brain, heart and muscle. COX15 defects are the cause of a neurodegenerative disorder known as Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).

Specifications

• Antigen: COX15
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.43 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: COX15
• Gene Accession No.: Q7KZN9, Q8BJ03
• Gene Alias: 2900026G05Rik; CEMCOX2; COX15; COX15 cytochrome c oxidase assembly homolog; COX15 homolog, cytochrome c oxidase assembly protein; COX15, cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly homolog 15; cytochrome c oxidase assembly homolog 15 (yeast); cytochrome c oxidase assembly protein 15; cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
• Gene Symbols: COX15
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human COX15 (NP_5108701).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1355, 226139, 309391
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG