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Invitrogen™ COX4I2 Polyclonal Antibody
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Catalog No. PIPA5116399
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200 μL
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PIPA5116399 200 μL
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Catalog No. PIPA5116399 Supplier Invitrogen™ Supplier No. PA5116399
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Description

Rabbit Polyclonal Antibody

COX4I2 Polyclonal Antibody for Western Blot

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [Uniprot].
TRUSTED_SUSTAINABILITY

Specifications

Antigen COX4I2
Applications Western Blot
Classification Polyclonal
Concentration 0.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene COX4I2
Gene Accession No. Q91W29, Q96KJ9
Gene Alias AL024441; COX; cox iv; COX IV-1; Cox IV-2; cox4; COX4-1; Cox4-2; Cox4a; Cox4b; cox4i1; cox4i1.S; Cox4i2; COX4L2; COXIV; COXIV-1; CoxIV-2; Cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; cytochrome c oxidase subunit 4I1; cytochrome c oxidase subunit 4I2; cytochrome c oxidase subunit IV; cytochrome c oxidase subunit IV isoform 1; cytochrome c oxidase subunit IV isoform 1 precursor; cytochrome c oxidase subunit IV isoform 1 S homeolog; cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit IV isoform 2 (lung); cytochrome c oxidase subunit IV precursor EC 1.9.3.1; cytochrome c oxidase subunit IV-like 2; cytochrome c oxidase, subunit 4a; cytochrome c oxidase, subunit 4b; cytochrome c oxidase, subunit IV; cytochrome c oxidase, subunit IVa; cytochrome c oxidase, subunit IVb; cytochrome c oxydase subunit 4; dJ857M17.2; FLJ23483; hypothetical protein MGC73355; IV-1; mg:bb02d03; MGC72016; XELAEV_18024950mg; zgc:110058; zgc:73355
Gene Symbols COX4I2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 141-171 amino acids from human COXIV Isoform 2.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84682, 84701
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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