Invitrogen™ COX7A2/COX7A3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599611

Catalog No. PIPA599611

Description

Antibody detects endogenous levels of total COX7a2/3.

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. COX7A2 is predicted to enable electron transfer activity, to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation, and to be part of mitochondrial respiratory chain complex IV.

Specifications

• Antigen: COX7A2/COX7A3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COX7A2P2
• Gene Alias: Cox7a2; Cox7a3; COX7AL; COX7AL1; COX7AL2; COXVIIAL; COXVIIa-L; cytochrome c oxidase polypeptide 7A2, mitochondrial; cytochrome c oxidase polypeptide VIIa-liver/heart; cytochrome c oxidase subunit 7A2; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 2; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa polypeptide 2; cytochrome c oxidase subunit VIIa polypeptide 2 (liver); cytochrome c oxidase subunit VIIaL; cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart; cytochrome c oxidase, subunit 7a 3; cytochrome c oxidase, subunit VIIa 2; hepatic cytochrome-c oxidase chain VIIa; VIIAL
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12866, 1347, 1348, 29507
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O60397, P14406, P35171, P48771
• Gene Symbols: COX7A2, COX7A2P2
• Immunogen: A synthesized peptide derived from human COX7A2P2(Accession O60397), corresponding to amino acid residues L5-H55.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG