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  5. Tocris Bioscience™ CP 122721 hydrochloride

Tocris Bioscience™ CP 122721 hydrochloride
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Catalog No. 364925
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25 mg
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Catalog No. Quantity
36-492-5 25 mg
36-495 5 mg
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Catalog No. 36-492-5 Supplier Tocris Bioscience™ Supplier No. 3649/25
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Description

High affinity NK1 receptor antagonist

CP 122721 hydrochloride is a high affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

Specifications

CAS 145877-52-7
Synonym (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride
Quantity 25 mg
Molecular Formula C20H23F3N2O2.2HCl
Formula Weight 453.33
Purity 98%
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