Potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000nM for CRF1 and CRF2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.
Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
CAS Number: 1013933-37-3
Solubility: Soluble to 50mM in water and to 100mM in DMSO
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