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  5. Tocris Bioscience™ CP 43

Tocris Bioscience™ CP 43
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Catalog No. 655810
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65-581-0 10 mg
65-585-0 50 mg
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Description

Potent TAOK inhibitor

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Specifications

Chemical Name or Material N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1′-biphenyl]-4-carboxamide
CAS 850467-66-2
Quantity 10 mg
Molecular Formula C25H24N2O2
Purity 98%
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