Invitrogen™ CPA6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589343

Catalog No. PIPA589343

Description

Immunogen sequence: SLSGYNYEVY HSLEEIQNWM HHLNKTHSGL IHMFSIGRSY EGRSLFILKL GRRSRLKRAV WIDCGIHARE WIGPAFCQWF VKEALLTYKS DPAMRKMLNH LYFYIMPVFN VDGYHFSWTN DRFWRKTRSR NSRFRCRGVD ANRNWKVKWC DEGASMHPCD DTYCGPFPES EPEVKAVANF LRKHRKHIRA YLSFHAYAQM LLYPYSYKYA TIPNFRCVES AAYKAVNALQ SVYGVRYRYG PASTTLYVSS GSSMDWAYKN GIPYAFAFEL RDTGYFGFLL PEMLIKPTCT ETMLAVKNIT MHLLKKCP; Positive Samples: HT-29, HepG2, HeLa; Cellular Location: extracellular matrix, extracellular space.

Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus, which is cleaved off upon enzyme activation. Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus. CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides. Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve). There are three isoforms of CPA6 that exist as a result of alternative splicing events.

Specifications

• Antigen: CPA6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CPA6
• Gene Alias: 9030616D13Rik; Carboxypeptidase A6; carboxypeptidase B; CPA6; CPAH; ETL5; FEB11; metallocarboxypeptidase; si:dkey-78n18.1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 312913, 329093, 57094
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.31 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q5U901, Q8N4T0
• Gene Symbols: CPA6
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-437 of human CPA6 (NP_0650943).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG