Invitrogen™ CPEB3 Polyclonal Antibody

Catalog No.	Quantity
PIPA590443	100 μL

Catalog No. PIPA590443 Supplier Invitrogen™ Supplier No. PA590443

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TFSPQIGLAQ TQHHQQPPPP APAPQPAQPA QPPQAQPPQQ RRSPASPSQA PYAQRSAAAA YGHQPIMTSK PSSSSAVAAA AAAAAASSAS SSWNTHQSVN AAWSAPSNPW GGLQAGRDPR RAVGVGVGVG VGVPSPLNPI SPLKKPFSSN VIAPPKFPRA APLTSKSWME DNAFRTDNGN NLLPFQDRSR PYDTFNLHSL ENSLMDMIRT DHEPLKGKHY PPSGPPMSFA DIMWRNHFAG RMGINFHHPG T; Positive Samples: Mouse heart, Mouse kidney, Rat heart.

Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation. Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception. Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation. Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). [UniProt].

Specifications

• Antigen: CPEB3
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 2.9 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: Cpeb3
• Gene Accession No.: Q7TN99, Q8NE35
• Gene Alias: 4831444O18Rik; CPEB3; CPE-binding protein 3; CPE-BP3; cytoplasmic polyadenylation element binding protein 3; cytoplasmic polyadenylation element-binding protein 3; hCPEB-3; KIAA0940; mKIAA0940; RGD1564670
• Gene Symbols: Cpeb3
• Host Species: Rabbit
• Immunogen: Recombinant protein (or fragment).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 208922, 22849, 309510
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov