Invitrogen™ CPEB4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115046

Catalog No. PIPA5115046

Description

Antibody detects endogenous levels of total CPEB4.

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. [UniProt].

Specifications

• Antigen: CPEB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CPEB4
• Gene Alias: CPEB4; Cpeb-4; CPE-binding protein 4; Cpe-bp4; cytoplasmic polyadenylation element binding protein 4; cytoplasmic polyadenylation element-binding protein 4; hCPEB-4; KIAA1673; mCPEB-4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 303010, 67579, 80315
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q17RY0, Q7TN98
• Gene Symbols: CPEB4
• Immunogen: A synthesized peptide derived from human CPEB4(Accession Q17RY0), corresponding to amino acid residues A420-Y470.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov