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Invitrogen™ CPEB4 Polyclonal Antibody
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Catalog No. PIPA5115046
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PIPA5115046 100 μL
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Catalog No. PIPA5115046 Supplier Invitrogen™ Supplier No. PA5115046
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CPEB4.

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen CPEB4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene CPEB4
Gene Accession No. Q17RY0, Q7TN98
Gene Alias CPEB4; Cpeb-4; CPE-binding protein 4; Cpe-bp4; cytoplasmic polyadenylation element binding protein 4; cytoplasmic polyadenylation element-binding protein 4; hCPEB-4; KIAA1673; mCPEB-4
Gene Symbols CPEB4
Host Species Rabbit
Immunogen A synthesized peptide derived from human CPEB4(Accession Q17RY0), corresponding to amino acid residues A420-Y470.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 303010, 67579, 80315
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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