CPS1 Antibody (CPS1/1022), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP24455100	Novus Biologicals NBP2445510.02MG	0.02 mg
NBP24455101	Novus Biologicals NBP2445510.1MG	0.1 mg
NBP24455102	Novus Biologicals NBP2445510.2MG	0.2 mg

Description

Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Immunofluorescence

CPS1 Monoclonal specifically detects CPS1 in Human, Canine samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: CPS1
• Concentration: 0.2mg/mL
• Applications: Immunohistochemistry (Paraffin), Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human, Canine
• Gene Accession No.: P31327
• Gene ID (Entrez): 1373
• Immunogen: Recombinant human CPS1 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

• Clone: CPS1/1022
• Dilution: Immunohistochemistry-Paraffin 0.25 - 0.5 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: carbamoyl-phosphate synthase [ammonia], mitochondrial, carbamoyl-phosphate synthase 1, mitochondrial, carbamoyl-phosphate synthetase 1, mitochondrial, carbamoylphosphate synthetase I, Carbamoyl-phosphate synthetase I, CPSase I, CPSASE1, EC 6.3.4.16
• Gene Symbols: CPS1
• Isotype: IgG1
• Purification Method: Protein A or G purified
• Test Specificity: This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

For Research Use Only