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CPS1 Antibody (SPM615), Novus Biologicals™
SDP

Catalog No. p-5539323 Shop All R&D Systems Products
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NBP24455200 0.02 mg
NBP24455201 0.1 mg
NBP24455202 0.2 mg
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Catalog No. NBP24455200 Supplier Novus Biologicals Supplier No. NBP2445520.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Immunofluorescence

CPS1 Monoclonal specifically detects CPS1 in Human, Canine samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen CPS1
Applications Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone SPM615
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin 0.25 - 0.5 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P31327
Gene Alias carbamoyl-phosphate synthase [ammonia], mitochondrial, carbamoyl-phosphate synthase 1, mitochondrial, carbamoyl-phosphate synthetase 1, mitochondrial, carbamoylphosphate synthetase I, Carbamoyl-phosphate synthetase I, CPSase I, CPSASE1, EC 6.3.4.16
Gene Symbols CPS1
Host Species Mouse
Immunogen Recombinant human CPS1 protein
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1373
Test Specificity This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
Target Species Human, Canine
Content And Storage Store at 4C.
Form Purified
Isotype IgG1
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