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Tocris Bioscience™ CPS2
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Catalog No. 78002
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Quantity:
2 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective CDK2 Degrader (PROTAC™)

CPS2 is a potent and selective CDK2 Degrader (PROTAC™) (IC50 = 24 nM). It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. It induces differentiation of AML cell lines, primary AML cells, and granulocytic differentiation of HSCs.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide
CAS 2756741-90-7
Quantity 2 mg
Target Active Degraders
Molecular Formula C38H42N12O10S2
Purity 98%
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