CPSF30 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-0759	Bethyl Laboratories, Inc A301584AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Specifications

• Antigen: CPSF30
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: CPSF30, NAR, NEB1, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, cleavage and polyadenylation specificity factor 30 kDa subunit, cleavage and polyadenylation specificity factor subunit 4, cleavage-polyadenylation specificity factor, 30kD, neb-1, no arches homolog, no
• Immunogen: Between 220 and 245
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: CPSF4

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: O95639, Q8BQZ5
• Gene ID (Entrez): 10898, 54188
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody