CR1 Mouse anti-Human, Clone: CR1/802, Abnova™

Catalog No.	Quantity
89-933-995	100 μg

Catalog No. 89-933-995 Supplier Abnova Corporation Supplier No. MAB13261

Description

Mouse monoclonal antibody raised against full length recombinant human CR1.

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq]

Specifications

• Antigen: CR1
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Classification: Monoclonal
• Clone: CR1/802
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against full length recombinant human CR1.
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 10mM PBS (0.05% BSA, 0.05% sodium azide).
• Gene Alias: C3BR/CD35/KN
• Gene Symbols: CR1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to full length human CR1.
• Purification Method: Protein A/G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1378
• Test Specificity: This monoclonal antibody does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2.
• Target Species: Human
• Content And Storage: Store at 4°C.
• Form: Liquid
• Isotype: IgG1 κ