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Invitrogen™ CRACC Monoclonal Antibody (520914)
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Catalog No. PIMA524227
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100 μg
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Catalog No. Quantity
PIMA524227 100 μg
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Catalog No. PIMA524227 Supplier Invitrogen™ Supplier No. MA524227
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Description

Rat Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant human CRACC is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRACC
Applications Flow Cytometry
Classification Monoclonal
Clone 520914
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene SLAMF7
Gene Accession No. Q8BHK6
Gene Alias 19A; 19A24; 19A24 protein; 4930560D03Rik; CD2 subset 1; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; CD319; CRACC; CS1; Leukocyte cell-surface antigen; membrane protein FOAP-12; Novel Ly9; novel LY9 (lymphocyte antigen 9) like protein; protein 19A; RGD1560190; SLAM family member 7; SLAMF7; UNQ576/PRO1138
Gene Symbols SLAMF7
Host Species Rat
Immunogen CHO-derived recombinant mouse CRACC/SLAMF7 Ala22-Gly224.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 75345
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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