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Invitrogen™ CRB2 Polyclonal Antibody
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Catalog No. PIPA560462
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100 μL
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PIPA560462 100 μL
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Catalog No. PIPA560462 Supplier Invitrogen™ Supplier No. PA560462
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RWDDGLRHLV MLSFGPDQLQ DLGQHVHVGG RLLAADSQPW GGPFRGCLQD LRLDGCHLPF FPLPLDNSSQ PSELGGRQSW NLT Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 75%.

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.
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Specifications

Antigen CRB2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CRB2
Gene Accession No. Q5IJ48
Gene Alias 5930402A21; BC043114; Crb2; crumbs 2; crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs2; crumbs-like protein 2; FSGS9; Protein crumbs homolog 2; RGD1309368; VMCKD
Gene Symbols CRB2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CRB2. Recombinant protein control fragment (Product #RP-100819).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 286204
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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