Invitrogen™ CRB2 Polyclonal Antibody

Catalog No.	Quantity
PIPA525628	400 μL

Catalog No. PIPA525628 Supplier Invitrogen™ Supplier No. PA525628

Description

Rabbit Polyclonal Antibody

CRB2 Polyclonal Antibody for IHC (P), Western Blot

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Specifications

• Antigen: CRB2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: CRB2
• Gene Accession No.: Q5IJ48, Q80YA8
• Gene Alias: 5930402A21; BC043114; Crb2; crumbs 2; crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs2; crumbs-like protein 2; FSGS9; Protein crumbs homolog 2; RGD1309368; VMCKD
• Gene Symbols: CRB2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 1258-1285 amino acids of human CRUM2.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 241324, 286204
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG