Tocris Bioscience™ CRBN-6-5-5-VHL

Catalog No.	Quantity
69-485	5 mg

Catalog No. 69-485

Supplier: Tocris Bioscience™ 6948/5

Description

Potent and selective cereblon Degrader (PROTAC™); cell-permeable

Potent and selective cereblon Degrader (PROTAC™) (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: (2 S,4 R)-1-((2 S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• CAS: 2362575-45-7
• Quantity: 5 mg
• Solubility: Soluble to 100mM in DMSO
• Target: Active Degraders
• Molecular Formula: C₅₁H₆₉N₇O₁₀S
• Formula Weight: 972.21
• Physical Form: Solid
• Color: Yellow
• Product Type: Degrader
• Purity: 96%