Invitrogen™ CRBN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA538037

Catalog No. PIPA538037

Description

A recommended positive control is human testis tissue lysate. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms. Predicted species reactivity based on immunogen sequence: Bovine: (94%).

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.

Specifications

• Antigen: CRBN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRBN
• Gene Alias: 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 297498, 51185, 58799
• Content And Storage: 4°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q56AP7, Q8C7D2, Q96SW2
• Gene Symbols: CRBN
• Immunogen: A 16 amino acid peptide near the carboxy terminus of human CRBN. The immunogen is located within the last 50 amino acids of CRBN.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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