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Invitrogen™ CRBN Polyclonal Antibody
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Catalog No. PIPA538037
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100 μg
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PIPA538037 100 μg
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Catalog No. PIPA538037 Supplier Invitrogen™ Supplier No. PA538037
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Description

Rabbit Polyclonal Antibody

A recommended positive control is human testis tissue lysate. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms. Predicted species reactivity based on immunogen sequence: Bovine: (94%).

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRBN
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CRBN
Gene Accession No. Q56AP7, Q8C7D2, Q96SW2
Gene Alias 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
Gene Symbols CRBN
Host Species Rabbit
Immunogen A 16 amino acid peptide near the carboxy terminus of human CRBN. The immunogen is located within the last 50 amino acids of CRBN.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 297498, 51185, 58799
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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