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Invitrogen™ CRBN Polyclonal Antibody
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Catalog No. PIPA561122
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100 μL
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Catalog No. Quantity
PIPA561122 100 μL
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Catalog No. PIPA561122 Supplier Invitrogen™ Supplier No. PA561122
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EVEDQDSKEA KKPNIINFDT SLPTSHTYLG ADMEEFHGRT LHDDDSCQVI PVLPQVMMIL IPGQTLPLQL FHPQEVSMVR NLIQKDRTFA VLAYSNVQER E Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRBN
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CRBN
Gene Accession No. Q56AP7, Q8C7D2, Q96SW2
Gene Alias 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
Gene Symbols CRBN
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CRBN. Recombinant protein control fragment (Product #RP-96271).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 297498, 51185, 58799
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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