Invitrogen™ CRBN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578492

Catalog No. PIPA578492

Description

Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS Predicted Reactivity: Mouse (92%), Rat (97%), Rhesus Monkey (99%), Bovine (90%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.

Specifications

• Antigen: CRBN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRBN
• Gene Alias: 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 297498, 51185, 58799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q56AP7, Q8C7D2, Q96SW2
• Gene Symbols: CRBN
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human CRBN. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG