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Tocris Bioscience™ CRBN PROTAC™ 14a
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Catalog No. 72195
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72-195 5 mg
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Catalog No. 72-195 Supplier Tocris Bioscience™ Supplier No. 7219/5
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Description

Cereblon Degrader (PROTAC™)

CRBN PROTAC® 14a is a cereblon Degrader (PROTAC™). Comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. Preferentially degrades cereblon (DC50 = 200 nM in HEK293 cells). Induces rapid and profound cereblon degradation (98% decrease after 8 h at 1 μM in HEK293 cells).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material N1-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-(-1-((2 S,4 R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide
CAS 2358775-70-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C53H72N8O13S
Purity 0.98
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