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Invitrogen™ CKMT1A Polyclonal Antibody
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Catalog No. PIPA5106347
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100 μL
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PIPA5106347 100 μL
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Catalog No. PIPA5106347 Supplier Invitrogen™ Supplier No. PA5106347
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CKMT1A.

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CKMT1A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CKMT1A
Gene Accession No. P12532, P25809, P30275
Gene Alias Acidic-type mitochondrial creatine kinase; CKMT; Ckmt1; CKMT1A; Ckmt1b; Creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1 (ubiquitous); creatine kinase, mitochondrial 1, ubiquitous; creatine kinase, mitochondrial 1A; creatine kinase, mitochondrial 1B; mia-CK; mi-CK; Mt-CK; ScCKmit; UbCKmit; Ubiquitous mitochondrial creatine kinase; U-MtCK
Gene Symbols Ckmt1, CKMT1A
Host Species Rabbit
Immunogen A synthesized peptide derived from human CKMT1A; CKMT1B(Accession P12532), corresponding to amino acid residues F30-T80.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12716, 29593, 548596
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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