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CREB1 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
$518.60
Specifications
| Antigen | CREB1 |
|---|---|
| Concentration | 0.29 mg/mL |
| Applications | Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-172-7795
|
Proteintech Group Inc
122081AP150UL |
150 μL |
Each of 1 for $518.60
|
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Description
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer′s Disease, histiocytoma and soft tissue melanoma.Specifications
| CREB1 | |
| Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation | |
| Unconjugated | |
| Rabbit | |
| Human, Mouse, Non-human Primate, Rat | |
| P15337, P16220, Q01147 | |
| 12912, 1385, 81646 | |
| CREB1 Fusion Protein Ag2852 | |
| Primary | |
| -20°C | |
| CREB1 |
| 0.29 mg/mL | |
| Polyclonal | |
| Liquid | |
| RUO | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| CREB, CREB 1, CREB1 | |
| Creb1 | |
| IgG | |
| Antigen Affinity Chromatography | |
| Antibody |
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