CREST Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech

Catalog No.	Quantity
50-225-6802	100 μL

Catalog No. 50-225-6802 Supplier Proteintech Group Inc Supplier No. CL48812439100UL

Description

Rabbit Polyclonal Antibody

CREST, also named as SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. The calculated molecular weight of CREST is about 43 kDa, but the modified of CREST protein is 55 kDa (PMID: 25888396). CREST exists some isoforms with calulated MV 43, 40, 33 and 29 kDa.

Specifications

• Antigen: CREST
• Applications: Immunofluorescence
• Classification: Polyclonal
• Concentration: 1000 μg/mL
• Conjugate: CoraLite 488
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Gene ID (Entrez): 26039
• Target Species: Human
• Form: Liquid
• Isotype: IgG