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Tocris Bioscience™ CRID3 sodium salt
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Catalog No. 547910
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Catalog No. Quantity
54-791-0 10 mg
54-795-0 50 mg
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Catalog No. 54-791-0 Supplier Tocris Bioscience™ Supplier No. 5479/10
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Description

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Specifications

Quantity 10 mg
Product Type CRID3 sodium salt
Purity 98%
Molecular Weight (g/mol) 426.46

For Research Use Only

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