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CRIg Mouse, anti-Mouse, R718, Clone: 17C9, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752146

Catalog No. BDB752146


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Description

Description

The 17C9 monoclonal antibody specifically recognizes Complement receptor of the immunoglobulin superfamily (CRIg) which is encoded by the Vsig4 (V-set and immunoglobulin domain containing 4) gene. CRIg is a ∼45 kDa single-pass type I transmembrane glycoprotein that contains a variable (V-type) immunoglobulin domain in its extracellular region which is required for binding complement components and promoting phagocytosis. CRIg is expressed on Kupffer cells and tissue resident macrophages, including a subset of resident peritoneal macrophages. CRIg binds complement fragments C3b and iC3b and plays important roles in innate and adaptive immunity. This complement receptor is involved in regulation of the complement cascade and serves as a phagocytic receptor in the clearance of pathogens, immune complexes, and apoptotic cells. CRIg-positive macrophages can reportedly function in the negative regulation of T-cell proliferation and IL-2 production.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CRIg
Monoclonal
R718
50 μg
Primary
Refrigerate Upon Arrival
Flow Cytometry
17C9
Mouse
RUO
Mouse
Liquid
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