Invitrogen™ CRIM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534411

Catalog No. PIPA534411

Description

A suggested positive control is Jurkat cell lysate. PA5-34411 can be used with blocking peptide PEP-1453.

CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.

Specifications

• Antigen: CRIM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCP
• Gene Alias: AW060220; CRIM2; CRIM-2; cysteine rich BMP regulator 2 (chordin like); cysteine rich BMP regulator 2 (chordin-like); cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; Gm793; KCP; Kcp1; KCP-1; kielin; kielin/chordin-like protein; Kielin/chordin-like protein 1; NET67; RGD1561119
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 296952, 333088, 375616
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q3U492, Q6ZWJ8
• Gene Symbols: KCP
• Immunogen: A 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG