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Invitrogen™ CRIM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534411

Catalog No. PIPA534411


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-34411 can be used with blocking peptide PEP-1453.

CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CRIM2
Polyclonal
Unconjugated
KCP
AW060220; CRIM2; CRIM-2; cysteine rich BMP regulator 2 (chordin like); cysteine rich BMP regulator 2 (chordin-like); cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; Gm793; KCP; Kcp1; KCP-1; kielin; kielin/chordin-like protein; Kielin/chordin-like protein 1; NET67; RGD1561119
Rabbit
Antigen affinity chromatography
RUO
296952, 333088, 375616
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q3U492, Q6ZWJ8
KCP
A 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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