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Cripto-1 TDGF1 Polyclonal Antibody, Rockland™
SDP

Catalog No. 501991911
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100 μg
25 μL
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50-199-1911 100 μg
50-199-1912 25 μL
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Catalog No. 50-199-1911 Supplier Rockland Immunochemicals Supplier No. 600401997
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Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This antibody is specific for human Cripto-1 protein. A BLAST analysis was used to suggest limited cross-reactivity with Cripto-1 from mouse based on a 70% homology with the immunizing sequence. Expect cross-reactivity with human Cripto-3 (TDGF2) based on very high levels of sequence conservation. Cross-reactivity with Cripto-1 from other sources has not been determined.

Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.

Specifications

Antigen Cripto-1 TDGF1
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene TDGF1
Gene Accession No. P13385
Gene Alias CR; CR1; CRGF; CRIPTO; cripto growth factor; Cripto-1; Cripto-1 growth factor; Cripto-3; epidermal growth factor-like Cripto protein; Epidermal growth factor-like cripto protein CR1; TDGF1; TDGF2; teratocarcinoma-derived growth factor; Teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
Gene Symbols TDGF1
Host Species Rabbit
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6997
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
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