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Invitrogen™ CrkL Monoclonal Antibody (5E12)
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Catalog No. PIMA515867
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100 μL
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Catalog No. Quantity
PIMA515867 100 μL
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Catalog No. PIMA515867 Supplier Invitrogen™ Supplier No. MA515867
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Description

Mouse Monoclonal Antibody

MA5-15867 targets CRKL in indirect ELISA, FACS and WB applications and shows reactivity with Human samples. The MA5-15867 immunogen is purified recombinant fragment of human CRKL expressed in E. Coli. . MA5-15867 detects CRKL which has a predicted molecular weight of approximately 39kDa.

The CRKL gene encodes the CRK-like protein, an adaptor protein that plays a crucial role in intracellular signaling pathways related to cell proliferation, differentiation, and migration. CRKL contains SH2 and SH3 domains that facilitate interactions with other signaling molecules, influencing multiple pathways such as the MAPK, PI3K, and STAT pathways. It is involved in processes like cytoskeleton reorganization and immune cell signaling, with significant implications for development and cancer. CRKL is notably associated with Philadelphia chromosome-positive leukemias, where it interacts with the BCR-ABL fusion protein, contributing to leukemogenesis. Additionally, dysregulation of CRKL can affect cardiovascular development, leading to congenital heart defects. Research into CRKL focuses on understanding its role in signal transduction and its potential as a therapeutic target due to its involvement in oncogenic and developmental pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CrkL
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 5E12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene CRKL
Gene Accession No. P46109, P47941
Gene Alias 1110025F07Rik; AA589403; AI325100; CRK like proto-oncogene, adaptor protein; CRKL; crkl {ECO:0000312; crk-like protein; crk-like protein {ECO:0000250; Crkol; EMBL:AAH85865.1, ECO:0000312; OTTHUMP00000198539; RGD:1308531}; UniProtKB:P46109}; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
Gene Symbols CRKL
Host Species Mouse
Immunogen Purified recombinant fragment of human CRKL expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12929, 1399
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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