Invitrogen™ CrkL Monoclonal Antibody (5E12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515867

Catalog No. PIMA515867

Description

MA5-15867 targets CRKL in indirect ELISA, FACS and WB applications and shows reactivity with Human samples. The MA5-15867 immunogen is purified recombinant fragment of human CRKL expressed in E. Coli. . MA5-15867 detects CRKL which has a predicted molecular weight of approximately 39kDa.

The CRKL gene encodes the CRK-like protein, an adaptor protein that plays a crucial role in intracellular signaling pathways related to cell proliferation, differentiation, and migration. CRKL contains SH2 and SH3 domains that facilitate interactions with other signaling molecules, influencing multiple pathways such as the MAPK, PI3K, and STAT pathways. It is involved in processes like cytoskeleton reorganization and immune cell signaling, with significant implications for development and cancer. CRKL is notably associated with Philadelphia chromosome-positive leukemias, where it interacts with the BCR-ABL fusion protein, contributing to leukemogenesis. Additionally, dysregulation of CRKL can affect cardiovascular development, leading to congenital heart defects. Research into CRKL focuses on understanding its role in signal transduction and its potential as a therapeutic target due to its involvement in oncogenic and developmental pathways.

Specifications

• Antigen: CrkL
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: P46109, P47941
• Gene Symbols: CRKL
• Immunogen: Purified recombinant fragment of human CRKL expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 12929, 1399
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 5E12
• Conjugate: Unconjugated
• Gene: CRKL
• Gene Alias: 1110025F07Rik; AA589403; AI325100; CRK like proto-oncogene, adaptor protein; CRKL; crkl {ECO:0000312; crk-like protein; crk-like protein {ECO:0000250; Crkol; EMBL:AAH85865.1, ECO:0000312; OTTHUMP00000198539; RGD:1308531}; UniProtKB:P46109}; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1