CRKRS Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 268161AP150UL

Catalog No. 50-173-5465

Description

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Specifications

• Antigen: CRKRS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDK12
• Gene Alias: CDC2 related protein kinase 7, CDK12, CRK7, CRKR, CRKRS, KIAA0904
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51755
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q9NYV4
• Gene Symbols: CDK12
• Immunogen: CRKRS Fusion Protein Ag25323
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG