Invitrogen™ CRMP5 Monoclonal Antibody (CR-1)

Catalog No.	Quantity
MA3-701	100 μL

Catalog No. MA3-701 Supplier Invitrogen™ Supplier No. MA3701

Description

Rat Monoclonal Antibody

MA3-701 detects human, bovine, rat and C-terminal region of CRMP5. This antibody has not been shown to be reactive in mouse samples. MA3-701 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract. The MA3-701 antigen is a purified protein from human brain. This antibody is specific for the C-terminal region, amino acids 369 - 564. Not reactive with other CRMP isoforms.

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Specifications

• Antigen: CRMP5
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: CR-1
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites with 0.05% sodium azide
• Gene: DPYSL5
• Gene Accession No.: Q9BPU6, Q9JHU0
• Gene Alias: collapsin response mediator protein 5; collapsin response mediator protein-5; CRAM; CRMP3-associated molecule; Crmp5; CRMP-5; dihydropyrimidinase like 5; dihydropyrimidinase-like 5; dihydropyrimidinase-related protein 5; Dpysl5; DRP-5; Ulip6; ULIP-6; ULIP6 protein; UNC33-like phosphoprotein 6
• Gene Symbols: DPYSL5
• Host Species: Rat
• Immunogen: CRMP5 protein purified from human brain.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100126171, 56896, 65208
• Target Species: Human, Rat, Bovine
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1