Invitrogen™ CRMP5 Recombinant Rabbit Monoclonal Antibody (5L4S8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542815

Catalog No. PIMA542815

Description

Positive test controls include: SH-SY5Y, Mouse testis, Rat testis. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: RSFPDTVYKK LVQREKTLKV RGVDRTPYLG DVAVVVHPGK KEMGTPLADT PTRPVTRHGG MRDLHESSFS LSGSQIDDHV PKRASARILA PPGGRSSGIW.

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Specifications

• Antigen: CRMP5
• Classification: Recombinant Monoclonal
• Concentration: 0.15 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BPU6, Q9EQF6, Q9JHU0
• Gene Symbols: DPYSL5
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 465-564 of human CRMP5/DPYSL5 (Q9BPU6).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 5L4S8
• Conjugate: Unconjugated
• Gene: DPYSL5
• Gene Alias: collapsin response mediator protein 5; collapsin response mediator protein-5; CRAM; CRMP3-associated molecule; Crmp5; CRMP-5; dihydropyrimidinase like 5; dihydropyrimidinase-like 5; dihydropyrimidinase-related protein 5; Dpysl5; DRP-5; Ulip6; ULIP-6; ULIP6 protein; UNC33-like phosphoprotein 6
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56896, 65208, 65254
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid