Invitrogen™ CRSP130 Monoclonal Antibody (4H6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA520718

Catalog No. PIMA520718

Description

Peptide Sequence: LTVHAKMSLI HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL.

CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription.

Specifications

• Antigen: CRSP130
• Classification: Monoclonal
• Concentration: 0.2-1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9ULK4
• Gene Symbols: MED23
• Immunogen: MED23 (NP_004821, 531 a.a. ~ 630 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: 4H6
• Conjugate: Unconjugated
• Gene: MED23
• Gene Alias: 130 kDa transcriptional co-activator; 130kDa; 133 kDa transcriptional co-activator; 3000002A17Rik; activator-recruited cofactor 130 kDa component; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); CRSP complex subunit 3; CRSP130; CRSP133; Crsp3; DRIP130; ESTM7; hSur-2; KIAA1216; Med23; Mediator complex subunit 23; mediator complex subunit MED23 variant MED23_i6; mediator complex subunit MED23 variant MED23_i7; mediator of RNA polymerase II transcription subunit 23; mKIAA1216; MRT18; mSur-2; Protein sur-2 homolog; SUR2; SUR-2; Transcriptional coactivator CRSP130; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component; X83317
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9439
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid