Invitrogen™ CRSP130 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587691

Catalog No. PIPA587691

Description

Immunogen sequence: LLKPNDFRNR VSDFVKENSP EHWLQNDWHT KHMNYHKKYP EKLYFEGLAE QVDPPVQIQS PYLPIYFGNV CLRFLPVFDI VIHRFLELLP VSKSLETLLD HLGGLYKFHD RPVTYLYNTL HYYEMHLRDR AFLKRKLVHA IIGSLKDNRP QGWCLSDTYL KCAMNAREEN PWVPDDTYYC RLIGRLVDTM AGKSPGPFPN CDWRFNEFPN PAAHALHVTC V; Positive Samples: Mouse brain, Rat brain; Cellular Location: Nucleus.

CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits. Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS. CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins. CRSP subunits also associate with larger multimeric co-activator complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription.

Specifications

• Antigen: CRSP130
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MED23
• Gene Alias: 130 kDa transcriptional co-activator; 130kDa; 133 kDa transcriptional co-activator; 3000002A17Rik; activator-recruited cofactor 130 kDa component; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3; cofactor required for Sp1 transcriptional activation, subunit 3 (130kD); CRSP complex subunit 3; CRSP130; CRSP133; Crsp3; DRIP130; ESTM7; hSur-2; KIAA1216; Med23; Mediator complex subunit 23; mediator complex subunit MED23 variant MED23_i6; mediator complex subunit MED23 variant MED23_i7; mediator of RNA polymerase II transcription subunit 23; mKIAA1216; MRT18; mSur-2; Protein sur-2 homolog; SUR2; SUR-2; Transcriptional coactivator CRSP130; vitamin D3 receptor interacting protein; Vitamin D3 receptor-interacting protein complex 130 kDa component; X83317
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309565, 70208, 9439
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.76 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q5EB59, Q80YQ2, Q9ULK4
• Gene Symbols: MED23
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 890-1110 of human MED23 (NP_0012574501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov