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Invitrogen™ CRTAM Polyclonal Antibody
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Catalog No. PIPA547185
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100 μg
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Catalog No. Quantity
PIPA547185 100 μg
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Catalog No. PIPA547185 Supplier Invitrogen™ Supplier No. PA547185
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Description

Goat Polyclonal Antibody

In sandwich ELISAs, less than 2% cross-reactivity with recombinant mouse CRTAM is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Class-I MHC-restricted T cell-associated molecule (CRTAM) is a gene located on chromosome 11q24.2, encoding a member of the immunoglobulin superfamily that plays a crucial role in immune cell interactions. CRTAM is expressed on activated CD8+ T cells, natural killer (NK) cells, and some subsets of CD4+ T cells, where it is involved in promoting cell adhesion, cytokine production, and cytotoxic responses. The protein binds to Necl-2 (CD112), mediating intercellular communication that influences immune responses, particularly in the context of viral infections and tumor surveillance. CRTAM's involvement in directing immune cell activity highlights its importance in the regulation of adaptive and innate immunity. Research into CRTAM is exploring its potential as a therapeutic target for modulating immune functions, aiming to enhance immune responses against cancer and infectious diseases or to attenuate autoimmune reactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRTAM
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene CRTAM
Gene Accession No. O95727
Gene Alias CD355; CD355 antigen; class I MHC restricted T cell associated molecule; class I-restricted T cell-associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule; Crtam; cytotoxic and regulatory T cell molecule; cytotoxic and regulatory T-cell molecule
Gene Symbols CRTAM
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human CRTAM Ser18-Ser286.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56253
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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