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MilliporeSigma™ CRTC1, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABE1952MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE1952MI 100 μL Unconjugated
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Catalog No. ABE1952MI Supplier MilliporeSigma™ Supplier No. ABE1952

Description

Rabbit Polyclonal Antibody

CREB-regulated transcription coactivator 1 (UniProt: Q6UUV9; also known as Mucoepidermoid carcinoma translocated protein 1;Transducer of regulated cAMP response element-binding protein 1;TORC-1;Transducer of CREB protein 1) is encoded by the CRTC1 (also known as MECT1; TORC1; WAMTP1; KIAA0616) gene (Gene ID 23373) in human. CRTC1 is a 67.3kDa protein that activates transcription through binding cAMP response element (CRE) sites on DNA. It is highly expressed in adult and fetal brain and is localized to specific regions such as the prefrontal cortex and cerebellum. Very low expression is observed in heart, spleen, lung, skeletal muscle, salivary gland, ovary, and kidney. Phosphorylation/dephosphorylation states of Ser151 are required for regulating transduction of CREB activity. It is mainly localized in the cytoplasm when phosphorylated by salt-induced kinase (SIK) or AMPK and when sequestered by 14-3-3 proteins. It is translocated to the nucleus upon dephosphorylation on Ser151. CRTC1 is shown to mediate early beta-amyloid-induced transcriptional and memory deficits and overexpression of CRTC1 is shown to rescue amyloid-induced transcriptional and cognitive deficits. CRTC1 is reported to ameliorate hippocampal-dependent learning and memory deficits in APPSw,Ind mice by enhancing the expression of a specific subset of CCTC1 target genes. A chromosomal aberration involving CRTC1 has been reported in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRTC1
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene CRTC1, MECT1, TORC1, WAMTP1, KIAA0616
Gene Accession No. Q6UUV9
Host Species Rabbit
Immunogen GST-tagged recombinat 135-amino acid fragment from the N-terminal region of human CRTC1.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NM_015321.2
Test Specificity ABE1952 detected a target band in lysates from mouse and rat CRTC1-transfected HEK293 cells.
Target Species Mouse
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
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For Research Use Only. Not for use in diagnostic procedures.

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