Invitrogen™ CRTH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588828

Catalog No. PIPA588828

Description

Immunogen sequence: GAMRNLYAMH RRLQRHPRSC TRDCAEPRAD GREASPQPLE ELDHLLLLAL MTVLFTMCSL PVIYRAYYGA FKDVKEKNRT SEEAEDLRAL RFLSVISIVD PWIFIIFRSP VFRIFFHKIF IRPLRYRSRC SNSTNMESSL; Positive Samples: NIH/3T3; Cellular Location: Cell membrane, Multi-pass membrane protein.

CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that is an identified receptor for the prostaglandin D2 (PGD2) and prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. CRTH2 is also a novel member of the G protein-coupled leukocyte chemoattractant receptor family, which is selectively expressed in Th2 but not Th1 lineage cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated: a 3.5 kb transcript expressed primarily in the thalamus, frontal cortex, pons and hippocampus; and a 3.4 kb transcript expressed in fetal liver, leukocytes and thymus. CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions. At least two different isoforms of CRTH2 are known to exist. Single nucleotide polymorphisms in the 3' UTR of the CRTH2 gene have been associated with asthma susceptibility.

Specifications

• Antigen: CRTH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTGDR2
• Gene Alias: CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; CRTH2; DL1R; DP2; G protein-coupled receptor 44; Gpr44; G-protein coupled receptor 44; Grp45; MGC130436; PGD2 receptor; prostaglandin D2 receptor 2; prostaglandin D2 receptor CRTH2; Ptgdr2; putative G-protein coupled receptor 44
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11251, 14764
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.63 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9Y5Y4, Q9Z2J6
• Gene Symbols: PTGDR2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-359 of human PTGDR (NP_0009441).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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