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Invitrogen™ CRX Polyclonal Antibody
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Catalog No. PIPA532182
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100 μL
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PIPA532182 100 μL
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Catalog No. PIPA532182 Supplier Invitrogen™ Supplier No. PA532182
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: SK-N-SH, mouse eye. Predicted reactivity: Mouse (96%), Rat (97%), Dog (92%), Cat (93%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controling the expression of melatonin synthesis genes. Furthermore, CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in the visual pathologies of CORD, Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes although there is no known correlation between the pathologic phenotype and genetic mutation. Missense mutations of the CRX gene affect the homeobox domain, whereas frameshift mutations affect the OTX domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRX
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Crx
Gene Accession No. O43186, O54751
Gene Alias Cone rod homeobox; cone-rod homeobox; cone-rod homeobox containing; cone-rod homeobox protein; CORD 2; CORD2; CRD; CRX; Crx1; LCA 7; LCA7; orthodenticle homeobox 3; OTX; OTX 3; OTX3
Gene Symbols Crx
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human CORD2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12951, 1406
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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