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CRYAA Monoclonal Antibody (OTI2H2), TrueMAB™, OriGene
SDP

Catalog No. 501675993
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50-167-5993 100 μL
50-253-9638 30 μL
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Catalog No. 50-167-5993 Supplier OriGene Supplier No. TA505529
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Description

Mouse Monoclonal Antibody

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.

Specifications

Antigen CRYAA
Applications Western Blot
Classification Monoclonal
Clone OTI2H2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CRYAA
Gene Accession No. P02489
Gene Alias CRYA1, CTRCT9, HSPB4
Gene Symbols CRYAA
Host Species Mouse
Immunogen Full length human recombit protein of human CRYAA produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1409
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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