CRYAB Mouse anti-Human, Rat, Clone: OTI6D11, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500583S

Catalog No. 50-167-1723

Description

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.

Specifications

• Antigen: CRYAB
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P02511, P23928
• Gene Symbols: Cryab
• Immunogen: Full length human recombit protein of human CRYAB produced in HEK293T cell.
• Quantity: 30 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: OTI6D11
• Conjugate: Unconjugated
• Gene: CRYAB
• Gene Alias: CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1410, 25420
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid