Invitrogen™ CRYBB1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5114293	100 μL

Catalog No. PIPA5114293 Supplier Invitrogen™ Supplier No. PA5114293

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SIIVSAGPWV AFEQSNFRGE MFILEKGEYP RWNTWSSSYR SDRLMSFRPI For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 93%; Zebrafish: 85%.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.

Specifications

• Antigen: CRYBB1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: Crybb1
• Gene Accession No.: P53674
• Gene Alias: 3110006K12Rik; BB1CRY; Beta-B1 crystallin; beta-crystallin B1; Beta-crystallin B1B; CATCN3; CRYB1; CRYB11; Crybb1; crystallin beta B1; crystallin, beta B1; CTRCT17; eye lens structural protein
• Gene Symbols: Crybb1
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the middle region of Human CRYBB1.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1414
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov