CRYBB2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
FEPA5145324	Invitrogen™ PA5145324	20 μL
FEPA5145323	Invitrogen™ PA5145323	200 μL

Description

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

Specifications

• Antigen: CRYBB2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat
• Gene Accession No.: P62696, P62697
• Gene ID (Entrez): 12961, 25422
• Immunogen: Recombinant Rat CRYbB2 protein, Pro17-Arg191 (Accession #P62697).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: Beta crystallin B2; Beta crystallin Bp; beta-B2 crystallin; Beta-crystallin B2; beta-crystallin Bp; CCA 2; CCA2; CRYB B2; CRYB2; Cryb-2; CRYB2A; CRYBB 2; CRYBB2; crystallin beta B2; crystallin, beta B2; CTA-221G9.7; CTRCT3; D22S665; eye lens structural protein; OTTHUMP00000198622; R.norvegicus CRYBB2 gene (crystallin, beta B2)
• Gene Symbols: Crybb2
• Isotype: IgG
• Purification Method: Protein A
• Gene: Crybb2