Invitrogen™ CSB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585198

Catalog No. PIPA585198

Description

Keep as concentrated solution. Predicted reactivity: Mouse (92%), Bovine (90%). Positive Control: 293T, A431, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Specifications

• Antigen: CSB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERCC6
• Gene Alias: 4732403I04; ARMD5; ATP-dependent helicase ERCC6; C130058G22Rik; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; CKN2; Cockayne syndrome group B protein; cockayne syndrome protein CSB; COFS; COFS1; CS group B correcting; CSB; DNA excision repair protein ERCC-6; DNA excision repair protein ERCC-6; ERCC6-PGBD3 fusion protein; ERCC excision repair 6, chromatin remodeling factor; ERCC6; ERCC6-PGBD3 fusion protein (isoform 1); excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; POF11; RAD26; UVSS1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2074, 306274, 319955
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.69 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q03468
• Gene Symbols: ERCC6
• Immunogen: Recombinant protein encompassing a sequence within the center region of human CSB.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov