CSF1R Mouse anti-Human, Clone: 6C7, Bioss

Catalog No.	Quantity
50-197-9842	100 μL

Catalog No. 50-197-9842 Supplier Bioss Supplier No. BSM51303M

Description

Mouse Monoclonal Antibody

CSF1R (colony stimulating factor 1 receptor) is a cytokine that controls the production, differentiation, and function of macrophages. CSF1R mediates most if not all of the biological effects of CSF1. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

Specifications

• Antigen: CSF1R
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 6C7
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
• Gene: Csf1r
• Gene Accession No.: P07333
• Gene Alias: AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; Fms; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; PDGFRB; Proto-oncogene c-Fms; proto-oncogene fms
• Gene Symbols: Csf1r
• Host Species: Mouse
• Immunogen: This CSF1R antibody is generated from a mouse immunized with a recombinant protein.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1436
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ