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Invitrogen™ CSK Monoclonal Antibody (5F3)
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Catalog No. PIMA515707
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100 μL
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Catalog No. Quantity
PIMA515707 100 μL
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Catalog No. PIMA515707 Supplier Invitrogen™ Supplier No. MA515707
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Description

Mouse Monoclonal Antibody

MA5-15707 targets CSK in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples. The MA5-15707 immunogen is purified recombinant fragment of human CSK expressed in E. Coli. MA5-15707 detects CSK which has a predicted molecular weight of approximately 50kDa.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CSK
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5F3
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene CSK
Gene Accession No. P32577, P41240, P41241
Gene Alias AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Symbols CSK
Host Species Mouse
Immunogen Purified recombinant fragment of human CSK expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12988, 1445, 315707
Target Species Human, Mouse, Rat, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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