Invitrogen™ CSK Monoclonal Antibody (C.678.4)

Rabbit Monoclonal Antibody

Supplier:  Invitrogen™ MA514915

Catalog No. PIMA514915

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other proteins.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

Specifications

• Antigen: CSK
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CSK
• Gene Alias: AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100154110, 12988, 1445, 315707
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Clone: C.678.4
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene Accession No.: P32577, P41240, P41241
• Gene Symbols: CSK
• Immunogen: Synthetic peptide corresponding to residues surrounding amino acid residue Val399 of human Csk.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey, Pig
• Product Type: Antibody
• Isotype: IgG